Synaptosomal-associated protein 47 (SNAP47)

Synaptosomal-associated protein 47 (SNAP47) is an atypical member of the SNAP (Soluble N-ethylmaleimide-sensitive factor Attachment Protein) family, classified as a Q-SNARE protein involved in intracellular membrane fusion events[3][1][4]. Unlike SNAP25, SNAP47 does not contribute directly to classical presynaptic neurotransmitter release but participates in alternative membrane fusion pathways, including postsynaptic AMPA receptor insertion during synaptic plasticity and regulated vesicle trafficking[1][4]. It plays a critical role in autophagosome-lysosome fusion during both bulk autophagy and mitophagy, regulated by reversible acetylation, which controls its ability to form SNARE complexes and recruit the HOPS tethering complex[2]. SNAP47 is widely expressed in the brain, especially in postsynaptic compartments but also in axonal terminals, supporting both presynaptic and postsynaptic functions[1]. Genetic association studies link SNAP47 to a risk of schizophrenia and non-small cell lung cancer, but its precise pathogenic roles remain under investigation[3]. There are no drugs or therapeutics directly targeting SNAP47, and it is not currently used as a biomarker or therapeutic target.

Other names

SNAP47Synaptosome associated protein 47C1orf142HEL170SVAP1Epididymis luminal protein 170Synaptosomal-associated protein 47 kDaESFI5812HEL-S-290Epididymis secretory protein Li 290Synaptosomal-associated 47 kDa proteinSynaptosomal-associated protein, 47kDa