Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Synaptotagmin-14 (SYT14)
- Target
- SYT14
- Molecular classification
- Other (member of the synaptotagmin family; not a classical receptor, enzyme, ion channel, transporter, or transcription factor)
01
Overview
Synaptotagmin-14 (SYT14) is a protein-coding gene and a member of the synaptotagmin family, which is involved in membrane trafficking and exocytosis of secretory vesicles, particularly in non-neuronal tissues. Unlike classical synaptotagmins, SYT14 is calcium-independent. Mutations in SYT14 cause autosomal recessive spinocerebellar ataxia 11 (SCAR11) and have been associated with neurodevelopmental disorders such as macrocephaly, cerebral atrophy, seizures, and developmental delay. SYT14 is thought to function through interactions involving protein heterodimerization and may share functional similarities with other synaptotagmins involved in vesicle trafficking in synaptic transmission[1][4][5].
- Other names
- Synaptotagmin XIVSytXIVsytXIVFLJ34198SCAR11synaptotagmin-14synaptotagmin XIV
02
Biological functions
Membrane traffickingExocytosis of secretory vesiclesCalcium ion bindingProtein heterodimerization activity
03
Disease associations
Neurodegenerative disease (spinocerebellar ataxia 11)Neurodevelopmental abnormalities
Beyond the preview
Go deeper on Synaptotagmin-14 (SYT14).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Synaptotagmin-14 (SYT14).