Synaptotagmin-15 (SYT15)

Synaptotagmin-15 (SYT15) is a member of the synaptotagmin family of membrane trafficking proteins and contains a transmembrane region and two C2 domains, characteristic of this protein family[2][4][5]. Unlike canonical synaptotagmins primarily characterized in neuronal synaptic vesicle fusion, SYT15 appears to function mainly in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues[2][4][5][6]. SYT15 is annotated as a calcium ion-binding protein and may regulate vesicle trafficking via interactions with the SNARE complex, though detailed mechanisms and interactions remain less well understood compared to other synaptotagmins[2][6]. Diseases associated with SYT15 include Infantile Parkinsonism-Dystonia 2, though broader disease roles and therapeutic targeting information are currently limited[2]. No interacting drugs, established mechanisms of drug action, biomarkers, or safety concerns have been reported in current resources.

Other names

Synaptotagmin XVCHR10SYTSytXVchr10 synaptotagminsynaptotagmin XV-aSYT15Bsynaptotagmin-15