Synaptotagmin-16 (SYT16)

Synaptotagmin-16 is a member of the synaptotagmin family of membrane-trafficking proteins, characterized by a transmembrane region and C-terminal C2 domains, but distinguished by its calcium-independent mechanism (unlike key neuronal synaptotagmins)[3][1][4]. It is predicted to facilitate the trafficking and exocytosis of secretory vesicles in non-neuronal tissues, binding phospholipids and likely participating in protein heterodimerization[3][4][6]. Unlike some other synaptotagmins, it does not bind calcium, and there are no known drugs targeting it or established biomarker or safety concerns. Diseases associated with variants in SYT16 include oculopharyngodistal myopathy 1 and phimosis[3]. Its paralog, SYT14, shares similarity but has distinct tissue roles. Overall, Synaptotagmin-16 is a membrane-associated vesicular trafficking protein with roles outside classical neurosecretion[3][4][1].

Other names

Synaptotagmin-16SYT16Strep14SYT14LSYT14Ryt14rCHR14SYTSynaptotagmin 14-like proteinSynaptotagmin XIV-related proteinSynaptotagmin XIV-relatedchr14 synaptotagminsynaptotagmin XVI

Not applicable; no drugs known to target Synaptotagmin-16