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Synaptotagmin-2 (SYT2)
- Target
- SYT2
- Molecular classification
- Synaptic vesicle protein, Calcium sensor
01
Overview
Synaptotagmin-2 (SYT2) is a synaptic vesicle membrane protein and a major calcium sensor that regulates neurotransmitter release at synapses. It contains two C2 domains (C2A and C2B) that bind calcium ions and phospholipids, triggering rapid fusion of synaptic vesicles with the presynaptic plasma membrane. SYT2 is essential for proper synaptic transmission, especially at neuromuscular junctions, and its loss leads to severe motor dysfunction and impaired synaptic transmission.
02
Mechanism of action
Calcium-dependent binding to phospholipids and SNARE proteins, triggering synaptic vesicle fusion and neurotransmitter release.
03
Biological functions
Neurotransmitter releaseCalcium-dependent exocytosisSynaptic vesicle fusionRegulation of synaptic transmission
04
Disease associations
Motor dysfunctionSynaptic transmission impairmentNeuromuscular junction disorders
05
Safety considerations
Potential for broad impact on synaptic transmission if targeted systemicallyCompensation by other synaptotagmin isoforms may limit therapeutic efficacy
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