Synaptotagmin-7 (SYT7)

Synaptotagmin-7 (SYT7) is a peripheral membrane protein and member of the synaptotagmin family of Ca2+ sensors, containing two C2 domains that mediate Ca2+-dependent binding to phospholipids and membranes[1][2][3]. SYT7 participates in multiple aspects of synaptic vesicle trafficking, including facilitating asynchronous neurotransmitter release, paired-pulse facilitation, and replenishment of synaptic vesicles following high activity[1]. It is primarily localized on the axonal plasma membrane, lysosomes, and dense core vesicles, with its precise roles and distribution dependent on cell type and post-translational modifications including γ-secretase-mediated cleavage and palmitoylation[1]. SYT7’s function is distinct from that of Synaptotagmin-1, primarily supporting synaptic plasticity and slower forms of vesicle fusion[1][2][3]. It is implicated in membrane repair and lysosomal exocytosis in non-neuronal cells as well[1]. Genetic or expression alterations in SYT7 have been linked to defects in synaptic vesicle cycling, plasticity, and potentially to neurodegenerative disease and cancer, although precise clinical roles remain under investigation[1][2].

Other names

Synaptotagmin 7Syt7SytVIISYT-VIISYTVIIIPCA-7PCANAP7Prostate cancer-associated protein 7MGC150517synaptotagmin VIIsynaptotagmin-7prostate cancer-associated protein 7

Inhibition of γ-secretase prevents SYT7 cleavage/processing, affecting its plasma membrane localization and function