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Synaptotagmin-9 (SYT9)
- Target
- SYT9
- Molecular classification
- Calcium sensor, SNARE complex-associated protein, Vesicle trafficking protein, Peripheral membrane protein
01
Overview
Synaptotagmin-9 is a calcium-binding, membrane-associated protein belonging to the synaptotagmin family, involved in Ca²⁺-dependent exocytosis of secretory vesicles in neurons and other secretory cells. It functions primarily as a calcium sensor that regulates SNARE-mediated vesicle fusion, participating in chemical synaptic transmission and vesicle trafficking. Mutations or altered function of SYT9 have been linked to certain forms of maturity-onset diabetes, and it may play a role in neurosecretory processes by controlling neurotransmitter release and hormone secretion at the cell membrane[1][3][4].
- Other names
- SYT9Synaptotagmin-9SytIXSynaptotagmin IXsynaptotagmin-9synaptotagmin IXsytIX
02
Biological functions
Regulation of vesicle-mediated transportChemical synaptic transmissionCalcium-dependent exocytosisCalcium ion sensor activityPhospholipid binding
03
Disease associations
Maturity-Onset Diabetes Of The Young, Type 1Potential role in neurological disorders (research context)
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