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Synergin gamma (SYNRG)
- Target
- SYNRG
- Molecular classification
- Other (accessory protein involved in vesicular trafficking; interacts with AP-1 clathrin-adaptor complex)
01
Overview
Synergin gamma (SYNRG) is an accessory protein that interacts specifically with the gamma subunit of the AP-1 clathrin-adaptor complex, which functions at the trans-Golgi network in the sorting and trafficking of certain membrane and secretory proteins. SYNRG acts as a linker, connecting the AP-1 complex to other molecular components involved in clathrin-coated vesicle formation and membrane trafficking, thus regulating protein sorting and trafficking between the trans-Golgi network and endosomes. Loss of function disrupts trafficking of key cargo proteins and regulated secretion from specialized organelles.
- Other names
- AP1GBP1SYNGMGC104959gamma-synerginadaptor-related protein complex 1 gamma subunit-binding protein 1AP1 gamma subunit binding protein 1
02
Biological functions
Membrane traffickingEndocytosisClathrin-coated vesicle formationIntracellular protein sorting
03
Disease associations
Chromosome 17q12 deletion syndromeMixed phenotype acute leukemia, B/myeloidOther (roles in post-Golgi membrane trafficking, relevant in specialized secretory pathways such as Weibel-Palade bodies in endothelial cells)
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