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Synovial fluid mechanical supplementation, primarily through viscosupplementation with hyaluronic acid (HA), is a therapeutic approach aimed at restoring the biomechanical properties of synovial fluid in joints affected by conditions like osteoarthritis. It involves injecting exogenous substances, mainly HA or its derivatives, into the joint space to improve lubrication, shock absorption, and reduce friction between articular surfaces. HA supplementation mimics healthy synovial fluid, providing both immediate biomechanical benefits and longer-term biological effects such as reduced inflammation and improved tissue homeostasis.
Restoration of synovial fluid viscosity and elasticity, boundary lubrication, anti-inflammation, chondroprotection, analgesia via interaction with cell receptors and modulation of immune responses.
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