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Target intelligence / Profile preview
SNARE Protein Complex (SNARE)
- Target
- SNARE
- Molecular classification
- Protein Complex, Membrane Fusion Protein
01
Overview
The SNARE protein complex is a highly conserved molecular machine essential for membrane fusion in eukaryotic cells. This complex mediates the fusion of transport vesicles with target membranes, such as during neurotransmitter release at synapses or general vesicular trafficking within cells. Its core structure is a four-helix bundle involving proteins like synaptobrevin, syntaxin, and SNAP-25. Bacterial neurotoxins target SNAREs, disrupting their function and leading to diseases like botulism and tetanus.
- Other names
- Soluble N-ethylmaleimide-sensitive factor attachment protein receptorv-SNAREt-SNARER-SNAREQ-SNARESynaptobrevin/VAMPSyntaxinSNAP25
02
Mechanism of action
Bacterial neurotoxins (e.g., botulinum and tetanus toxins) cleave SNARE proteins, preventing vesicle fusion and neurotransmitter release.
03
Biological functions
Membrane fusionVesicular traffickingExocytosisNeurotransmitter releaseHormone secretionEndocytosis
04
Disease associations
BotulismTetanusNeurological Disorders
05
Safety considerations
Inhibition of SNARE complex function can lead to severe neurological deficits.Dysregulation can impact neurotransmission, hormone secretion, and general cell physiology.
06
Interacting drugs
Botulinum toxin
1 more in the full profile.
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