Syntaxin-18 (STX18)

Syntaxin-18 (STX18) is a member of the syntaxin family of SNARE proteins, critical for targeting and fusion of vesicles, especially those trafficking between the endoplasmic reticulum (ER) and Golgi complex[1]. As part of multiple SNARE complexes—including partnerships with proteins such as SNAP23, SEC22B, BNIP1, and USE1—it is essential for vesicular transport and membrane fusion processes like Golgi-to-ER retrograde transport, lipid droplet fusion, and secretion of specific bulky proteins such as procollagen VII[2][3][4]. Syntaxin-18 is also implicated in ER-mediated phagocytosis and the maintenance and expansion of ER subdomains. Mutations or dysfunction in STX18 have been associated with genetic diseases such as infantile liver failure syndrome[1]. To date, it has not been directly targeted by approved drugs, nor is it used as a clinical biomarker or therapeutic agent.

Other names

Syntaxin-18STX18GIG9Ufe1Cell growth-inhibiting gene 9 protein

Not applicable (no drugs currently known to target Syntaxin-18 directly)