Syntaxin 18 pseudogene 1 (STX18P1)

Syntaxin 18 pseudogene 1 (STX18P1) is a human pseudogene located on chromosome 17, annotated as ENSG00000266876[7][4]. Pseudogenes are DNA sequences similar to known genes but typically nonfunctional due to the absence of coding potential or regulatory elements needed for expression[5]. STX18P1 shares sequence similarity with the protein-coding syntaxin 18 (STX18), which is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus[1]. As a pseudogene, STX18P1 does not encode a functional protein and is not considered a therapeutic target[7][5]. There is no evidence in current sources to support a direct functional, disease, or pharmacological role for STX18P1. Syntaxin 18 itself (not the pseudogene) is a vesicular transport SNARE protein with roles in membrane fusion and autophagy. A functional relationship between pseudogenes and their parental genes can sometimes exist through competing endogenous RNA or miRNA-decoy mechanisms, but no such role for the STX18 pseudogene has been described in available literature[2][5]. STX18P1 does not have established drug interactions or mechanisms of pharmacological action[7][4].

Other names

Syntaxin 18 pseudogeneSTX18P1ENSG00000266876100418889 (NCBI Gene)