Syntaxin-1B (STX1B)

Syntaxin-1B (STX1B) is a synaptic membrane protein and a member of the SNARE protein family, encoded by the STX1B gene in humans[3][4]. It plays a critical role in the fusion of synaptic vesicles with the presynaptic plasma membrane, thus regulating neurotransmitter release at chemical synapses[2][4]. Syntaxin-1B contains an N-terminal peptide and an Habc domain, both interacting with Munc18-1 (also known as STXBP1), by independent mechanisms essential for vesicle fusion regulation[2]. Pathogenic variants in STX1B are associated with early-onset epilepsy and neurodevelopmental disorders[1]. It is highly expressed in neurons and orchestrates both spontaneous and evoked synaptic transmission by engaging in SNARE complex formation with other vesicular proteins[2][4]. There are no approved drugs that directly target Syntaxin-1B, but it serves as a genetic biomarker for specific epileptic syndromes.

Other names

Syntaxin-1BSTX1BSTX1B1STX1B2Syntaxin-1B1Syntaxin-1B2GEFSP9syntaxin-1Bsyntaxin-1B1syntaxin-1B2

No small-molecule drugs known to act directly on Syntaxin-1B; mechanisms would involve modulation of SNARE-mediated synaptic transmission or indirect pathways