Syntaxin-7 (STX7)

Syntaxin-7 is a membrane SNARE protein of the syntaxin family encoded by the STX7 gene. It mediates endosomal trafficking, including homotypic fusion of late endosomes and heterotypic fusion with lysosomes. Syntaxin-7 forms complexes with other SNARE proteins, including STX8, Vti1b, VAMP7, and VAMP8, and is essential for proper cargo delivery and membrane dynamics. It modulates invadopodia formation and extracellular matrix degradation in cancer cells, facilitating invasion, and also contributes to synaptic vesicle recycling in neurons during high-frequency stimulation[1][2][4][5]. Syntaxin-7 interacts with proteins such as alpha-SNAP, STX8, VAMP7/VAMP8, SNAP23, VAMP2, VAMP3, VPS18, and VPS11, highlighting its complex regulation in vesicular compartments[1][3][5]. Syntaxin-7 is best classified as a membrane trafficking SNARE essential for vesicle fusion and cellular invasion processes, with emerging relevance in cancer biology and neurobiology[1][2][4][5].

Other names

STX7Syntaxin 7syntaxin-7

N/A; no approved drugs or clinical candidates directly target Syntaxin-7. Experimental evidence shows that altering STX7 function can affect cancer cell invasion and synaptic vesicle replenishment, but this involves genetic or protein-level modulation rather than small-molecule or antibody drugs