Syntaxin-8 (STX8)

Syntaxin-8 (STX8) is a Qc-SNARE protein and member of the syntaxin family involved in the regulation of vesicular transport, specifically in protein trafficking from early to late endosomes via vesicle fusion and exocytosis[1][4][6]. It contributes to the formation of SNARE complexes, notably associating with syntaxin 7, vti1b, and endobrevin, and regulates trafficking to the plasma membrane of key molecules such as the cystic fibrosis transmembrane conductance regulator (CFTR), influencing chloride channel activity[1][2][6]. STX8 also participates in membrane fusion steps in the early secretory pathway, possibly mediating retrograde transport from Golgi to ER[4][6]. In platelets, it controls dense granule secretion and impacts aggregation and thrombus formation, while in epithelial cells, it regulates recycling of tight junction components like Claudin-16, modulating paracellular ion permeability[1]. There is emerging evidence for its role in the unconventional secretion of misfolded tau protein, with possible implications for neurodegenerative disease[1]. Additionally, it has been implicated (though not yet conclusively) in metabolic homeostasis, obesity, and type 2 diabetes through its influence on endosomal transport in adipose tissue[1]. While associated with several biological and disease pathways, Syntaxin-8 is not currently an established therapeutic target for any approved drugs.

Other names

CARBCIP-1-associated regulator of cyclin Bsyntaxin 8Stx80610007H08Rik1110002H11Rik4930571E13Rik