Syntaxin-binding protein 5 (STXBP5)

Syntaxin-binding protein 5 (STXBP5), also known as tomosyn, is a large cytosolic protein that regulates membrane fusion events in exocytosis, primarily by binding syntaxins, which are core components of the SNARE complex. In the nervous system, STXBP5 inhibits synaptic vesicle priming and neurotransmitter release, while in platelets and endothelial cells, it modulates regulated secretion (exocytosis) of granule contents, including von Willebrand factor and P-selectin. Animal studies show that loss of STXBP5 impairs platelet secretion and hemostasis, but increases endothelial exocytosis, highlighting its dual roles. Genetic variations in STXBP5 are associated with altered plasma vWF levels and risk of thrombotic disorders, implicating it as a regulatory factor in cardiovascular disease pathways, although it is not currently a direct therapeutic target[1][2][3][5].

Other names

TomosynTomosyn-1LLGL3Lethal(2) giant larvae protein homolog 3Nbla04300LGL3