Syntenic Cardiovascular Conserved Region-Associated long non-coding RNA 6 (SCAR-6 (F10-AS2))

Syntenic Cardiovascular Conserved Region-Associated long non-coding RNA 6 (SCAR-6; F10-AS2) is a bi-exonic, polyadenylated enhancer lncRNA transcribed antisense to the 3′ UTR of the coagulation factor X (F10) gene, upstream of the PROZ gene in a highly conserved syntenic block. The locus is functionally conserved across vertebrates, with human ortholog present on chromosome 13. SCAR-6 (F10-AS2) epigenetically regulates the expression of coagulation factor genes, especially PROZ, and maintains vascular homeostasis. Loss of function (via deletion or structural alteration) leads to impaired endothelial activation, hemorrhage, and hemostatic dysfunction, highlighting its importance in cardiovascular and coagulation systems. While no approved drugs target SCAR-6 itself, it remains a significant genetic and potential therapeutic target for coagulation and vascular health, with ongoing experimental studies elucidating its complex mechanisms of action and regulatory modalities

Other names

F10-AS2SCAR-6Syntenic Cardiovascular Conserved Region-Associated lncRNA-6

Drugs or genetic interventions targeting SCAR-6 (F10-AS2) would act by modulating its expression or function, which in turn affects the epigenetic regulation of neighboring genes such as F10 (coagulation factor X) and PROZ (protein Z-dependent protease inhibitor)