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Target intelligence / Profile preview
SYS1 golgi trafficking protein (SYS1)
- Target
- SYS1
- Molecular classification
- Other (integral membrane protein, Golgi-localized), Trafficking protein
01
Overview
SYS1 golgi trafficking protein is an integral membrane protein involved in vesicular trafficking within the cell, particularly associated with the Golgi apparatus[1][5]. SYS1 forms a complex with ARFRP1 (ADP-ribosylation factor-related protein 1) and is responsible for targeting ARFRP1 to the Golgi membrane, which is essential for normal protein sorting and trafficking[1][5]. It is predicted to play a role in transporting proteins from the Golgi to endosomes and the plasma membrane, and ensuring proper protein localization in the Golgi[2]. While associated with certain diseases such as familial hypertrophic cardiomyopathy type 13, there is currently no evidence supporting SYS1 as a direct therapeutic target or its involvement in drug interactions[1].
- Other names
- Protein SYS1 homologC20orf169DJ453C12.4DJ453C12.4.1SYS1 Golgi-localized integral membrane protein homologChromosome 20 open reading frame 169
02
Biological functions
Protein traffickingGolgi to endosome transportGolgi to plasma membrane protein transportProtein localization to Golgi apparatus
03
Disease associations
Cardiomyopathy, familial hypertrophic, 13 (disease association reported, but not a primary disease driver)
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