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Target intelligence / Profile preview
System L Amino Acid Transporter (LAT)
- Target
- LAT
- Molecular classification
- Transporter, Amino Acid Transporter
01
Overview
System L amino acid transporters are a family of sodium-independent proteins responsible for importing large neutral essential amino acids into mammalian cells. They play vital roles both physiologically—in supporting tissue nutrition—and pathologically—in enabling rapid cancer cell proliferation. Their unique structure-function relationship makes them important targets both pharmacologically (for inhibitor development) and biotechnologically (as drug delivery portals).
- Other names
- L-type Amino Acid TransporterSLC7A5 (LAT1)SLC7A8 (LAT2)SLC43A1 (LAT3)SLC43A2 (LAT4)
02
Mechanism of action
Inhibition of amino acid transport, leading to reduced nutrient uptake and suppressed cell growth.
03
Biological functions
Amino acid transportNutrient uptakeProtein synthesis regulationmTORC1 signaling pathway activationCell growthCell proliferation
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Potential for off-target effects on normal tissues expressing System L transportersPossible disruption of amino acid homeostasis
06
Interacting drugs
LAT1 inhibitors
07
Biomarkers
LAT1 expression levels in tumors
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