Systemic glucose metabolism and immune pathways

Systemic glucose metabolism and immune pathways represent a complex network of physiological processes rather than a single molecular target. This system encompasses the hormonal regulation of blood sugar levels and the activation of immune cells, which are intrinsically linked through the field of immunometabolism (Nature Reviews Immunology, 2017). In conditions like type 2 diabetes, chronic overnutrition leads to metabolic stress that triggers inflammatory pathways, while immune cells themselves require precise glucose regulation to function effectively during infection or injury (Cell Metabolism, 2016). Therapeutic intervention in this area typically involves targeting specific enzymes or receptors within these pathways, such as the insulin receptor or various cytokines, to restore homeostasis. Because the term describes a broad set of biological interactions and not a specific protein or gene product, it is classified as an incorrect target designation for drug discovery purposes.

Other names

ImmunometabolismGlucose-immune axisMetabolic-immune crosstalkMetainflammation

Modulation of systemic energy balance and inflammatory signaling cascades to restore physiological homeostasis.