Systemic metabolic and tissue repair pathways via nutrient provision

Systemic metabolic and tissue repair pathways via nutrient provision refers to a therapeutic strategy that utilizes specific combinations of endogenous metabolites, primarily amino acids, to simultaneously modulate multiple dysregulated biological pathways (Axcella Health, 2021). This approach, pioneered by companies like Axcella Health, aims to restore metabolic homeostasis and promote tissue repair in complex, multi-factorial diseases such as non-alcoholic steatohepatitis (NASH), hepatic encephalopathy, and muscle wasting (Harrison et al., 2021; Mann et al., 2020). Unlike traditional single-target drugs, this strategy leverages the natural signaling and metabolic roles of nutrients to influence systemic health. By providing precise ratios of amino acids, these therapies can activate anabolic pathways (e.g., mTORC1), inhibit catabolic processes, and improve mitochondrial function (Hamill et al., 2020). This multi-targeted mechanism is designed to address the underlying metabolic dysfunction that drives disease progression and tissue damage. It represents a systems-biology approach to medicine, focusing on the restoration of physiological balance rather than the inhibition of a single enzyme or receptor.

Other names

Endogenous Metabolic Modulators (EMMs)Metabolic Reprogramming via Amino AcidsNutritional TherapySystemic Metabolic Pathways

Simultaneous modulation of multiple metabolic and signaling pathways (e.g., mTOR, AMPK, insulin signaling) through the provision of specific ratios of amino acids and other endogenous metabolites to restore homeostasis and promote tissue repair.