T-box transcription factor 15 (TBX15)

T-box transcription factor 15 (TBX15) is a member of the T-box family of evolutionarily conserved transcription factors, characterized by a T-box DNA-binding domain[2][6]. TBX15 is essential in embryonic development, primarily regulating the formation and differentiation of the mesoderm, influencing limb, vertebral, and craniofacial skeletal structures, specifically the scapula[1][6]. TBX15 also coordinates adipocyte differentiation, particularly in brown and brite adipose tissue, and affects mitochondrial content. Loss-of-function mutations in TBX15 cause the rare congenital disorder Cousin syndrome, characterized by craniofacial, limb, and scapular malformations[2]. Mutations may also affect skin/fur patterning and growth. Overexpression of TBX15 has been observed in some cancers, where it may suppress apoptosis, and abnormal methylation status is implicated in poor placental outcomes and intrauterine growth restriction[1]. If additional information on TBX15 as a therapeutic target emerges in the future (such as targeted drug development), this assessment may change, but as of now, TBX15 is primarily a gene of developmental and biomarker significance, not a typical drug target.

Other names

TBX15Tbx15TBX14 (previous symbol)T-box protein 15