T-box transcription factor 6 (TBX6)

T-box transcription factor 6 (TBX6) is a phylogenetically conserved transcription factor characterized by a T-box DNA-binding domain, regulating genes involved in embryonic development. TBX6 is critical for specifying paraxial mesoderm identity and orchestrating somitogenesis, the process that produces somites—the segmented precursors of the vertebral column and ribs. Loss or mutation of TBX6 disrupts normal axial patterning and vertebral development, leading to congenital disorders such as congenital scoliosis. TBX6 functions in gene regulatory networks, interacting with other T-box family members, and represses or activates downstream targets in context-dependent manners.

Other names

T-box protein 6T-box 6T-box transcription factor TBX6SCDO5

No established drugs or small molecules are known to act on TBX6; its action is through sequence-specific DNA binding to regulate gene expression