Target intelligence / Profile preview

T Lymphocyte (None)

Target
None
Molecular classification
Lymphocyte, White blood cell, Immune cell
01

Overview

T lymphocytes, or T cells, are a type of white blood cell that play a central role in the adaptive immune system. They originate from hematopoietic stem cells in the bone marrow and mature in the thymus. T cells mediate immune responses by recognizing peptide fragments bound to MHC molecules on antigen-presenting cells. Upon activation, they proliferate and differentiate into various subtypes with specialized functions, including cytotoxic T cells, helper T cells, regulatory T cells, follicular helper T cells, and memory T cells. Dysfunction or deficiency in T cells can lead to immunodeficiency disorders, increased susceptibility to infections, autoimmune diseases, or failure in tumor surveillance.

Other names
T CellT-Lymphocyte
02

Mechanism of action

N/A

03

Biological functions

Adaptive immunityCytotoxicityHelper functionsRegulation/suppressionAntigen recognition
04

Disease associations

Immunodeficiency disordersInfectionsAutoimmune diseasesCancer
05

Safety considerations

ImmunodeficiencyAutoimmunityCytokine storm
06

Biomarkers

CD4+CD8+CD25+FOXP3+CXCR5+BCL-6+

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