Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
T-cell antigen CD7 (CD7)
- Target
- CD7
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily
01
Overview
CD7 is a transmembrane glycoprotein and a member of the immunoglobulin superfamily, primarily expressed on T cells, natural killer (NK) cells, and their precursors. It acts as a costimulatory molecule involved in T cell activation and differentiation and plays a role in immune response modulation, including apoptosis. It is a target for immunotherapies, particularly CAR-T therapies, for treating hematologic malignancies, but fratricide among CAR-T cells remains a challenge. CD8+ T cell populations can be subdivided based on surface levels of CD7, with high levels indicating naive/memory subsets and low/negative levels indicating effector populations.
02
Mechanism of action
Antibody-mediated cytotoxicity; CAR-T cell mediated cytotoxicity; Apoptosis induction via galectin-1 binding
03
Biological functions
Costimulation in immunityApoptosisImmune response modulationT cell activationT cell differentiation
04
Disease associations
T-cell acute lymphoblastic leukemia (T-ALL)Peripheral T-cell lymphomasAcute myeloid leukemia (AML)
05
Safety considerations
Fratricide among CAR-T cellsOn-target, off-tumor toxicity
06
Interacting drugs
Anti-CD7 antibody-drug conjugates
1 more in the full profile.
07
Biomarkers
CD7 expression level in T-ALLCD7 expression level in AML
Beyond the preview
Go deeper on T-cell antigen CD7 (CD7).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on T-cell antigen CD7 (CD7).