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Target intelligence / Profile preview
T-cell antigen CD7 (CD7)
- Target
- CD7
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily
01
Overview
CD7 is a transmembrane glycoprotein and a member of the immunoglobulin superfamily, primarily expressed on T cells, natural killer (NK) cells, and their precursors. It acts as a costimulatory molecule involved in T cell activation and differentiation and plays a role in immune response modulation, including apoptosis. It is a target for immunotherapies, particularly CAR-T therapies, for treating hematologic malignancies, but fratricide among CAR-T cells remains a challenge. CD8+ T cell populations can be subdivided based on surface levels of CD7, with high levels indicating naive/memory subsets and low/negative levels indicating effector populations.
02
Mechanism of action
Antibody-mediated cytotoxicity; CAR-T cell mediated cytotoxicity; Apoptosis induction via galectin-1 binding
03
Biological functions
Costimulation in immunityApoptosisImmune response modulationT cell activationT cell differentiation
04
Disease associations
T-cell acute lymphoblastic leukemia (T-ALL)Peripheral T-cell lymphomasAcute myeloid leukemia (AML)
05
Safety considerations
Fratricide among CAR-T cellsOn-target, off-tumor toxicity
06
Interacting drugs
Anti-CD7 antibody-drug conjugates
1 more in the full profile.
07
Biomarkers
CD7 expression level in T-ALLCD7 expression level in AML
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