T Cell Antigen Targets (T Cell Ag Targets)

T cell antigen targets are molecules, typically proteins or peptides, expressed on the surface of cells that can be recognized by T cell receptors (TCRs) or engineered receptors such as chimeric antigen receptors (CARs). These antigens are crucial for directing T cell-mediated immune responses, especially in cancer immunotherapy, where they enable the immune system to distinguish and attack malignant cells. They include tumor-associated antigens (TAAs), tumor-specific antigens/neoantigens, and viral-derived antigens. Targeting these antigens is key for adoptive cell therapies like CAR-T and TCR-T cell therapies.

Other names

Tumor-associated antigens (TAAs)Tumor-specific antigensNeoantigensViral-derived antigensMHC-presented peptidesCAR-T cell targetsTCR ligands

T cell receptor (TCR) or chimeric antigen receptor (CAR) binding, T cell activation, target cell lysis