Apoptosis Pathway in Activated T-Cells

The apoptosis pathway in activated T-cells is a tightly regulated process essential for immune homeostasis. After an immune response, the majority of activated T-cells are eliminated via apoptosis to prevent excessive or prolonged immune activity and autoimmunity. This process involves both intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways, with multiple molecular players orchestrating the decision between cell survival and programmed cell death. Key components include Bcl-2 family proteins (Bim, Puma, Bax, Bak, Bcl-2), cytochrome c, APAF1, caspases, Fas/FasL, TNFR1, TRAIL receptors, FADD, and TRADD. The pathway is triggered by cytokine withdrawal, persistent antigen stimulation (AICD), and cytotoxic T lymphocyte interactions. It functions to maintain immune balance and prevent autoimmunity. Pathway regulation is modulated by cytokines.

Other names

T-cell apoptosisActivated T-cell deathAICD (Activation-Induced Cell Death)