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Target intelligence / Profile preview
T-cell Co-receptor Cluster of Differentiation 4 (CD4)
- Target
- CD4
- Molecular classification
- Transmembrane glycoprotein, Receptor, Cluster of Differentiation (CD) molecule
01
Overview
CD4 is an indispensable co-receptor that enables efficient recognition and response against pathogens presented via MHC class II pathways—serving both structural/adherence roles at immunological synapses and acting as a molecular switchboard linking extracellular cues from APCs directly into potent intracellular signaling events driving adaptive immunity.
02
Mechanism of action
Modulation/blockade or depletion of CD4+ T cells
03
Biological functions
Co-receptor activitySignal amplificationAdhesionT cell development and selectionImmune response
04
Disease associations
HIV InfectionAutoimmunityImmunodeficiencyTransplant rejection
05
Safety considerations
ImmunosuppressionIncreased risk of infectionPotential for off-target effects
06
Interacting drugs
Anti-CD4 antibodies
07
Biomarkers
CD4 counts (HIV/AIDS management)
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