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Target intelligence / Profile preview
T-cell costimulatory molecule B7.1 (CD80)
- Target
- CD80
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane glycoprotein, B7 family
01
Overview
CD80 (B7.1) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily, primarily expressed on activated antigen-presenting cells (APCs). It plays a crucial role in T-cell activation by providing costimulatory signals through interaction with CD28, leading to T-cell proliferation, cytokine production, and differentiation. CD80 also interacts with CTLA4 (CD152), delivering inhibitory signals that downregulate immune responses, critical for maintaining self-tolerance. As a central regulator of adaptive immunity, CD80 is a target for immunotherapy in cancer and autoimmune diseases.
- Other names
- B7-1Cluster of Differentiation 80
02
Mechanism of action
Modulation of CD28/CTLA4 signaling
03
Biological functions
Immune regulationT-cell costimulationT-cell activationCytokine productionT-cell proliferationMaintaining self-tolerancePreventing autoimmunity
04
Disease associations
Autoimmune diseasesMultiple sclerosisSystemic lupus erythematosusGlomerular diseases (Minimal Change Nephropathy)Infectious diseasesHIVCancerAllograft rejection
05
Safety considerations
Potential for immune-related adverse eventsRisk of infection
06
Interacting drugs
Abatacept
07
Biomarkers
CD80 expression level in autoimmune diseasesCD80 expression on APCs
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