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Target intelligence / Profile preview
T-cell Factor Family of Transcription Factors (TCF/LEF)
- Target
- TCF/LEF
- Molecular classification
- Transcription factor
01
Overview
The T-cell factor (TCF) family, also known as TCF/LEF, comprises a group of transcription factors crucial for gene regulation downstream of the canonical Wnt signaling pathway. Key members include TCF7 (TCF1), LEF1, TCF7L1 (TCF3), and TCF7L2 (TCF4). These proteins bind DNA via their HMG box domain, modulating gene expression by interacting with co-factors like β-catenin or Groucho/TLE. They are vital for development, stem cell maintenance, and have been implicated in diseases such as cancer and diabetes due to their role in regulating developmental pathways.
- Other names
- T-cell factorLymphoid enhancer-binding factor
02
Mechanism of action
Modulation of Wnt signaling pathway; recruitment of co-repressors or co-activators to target gene promoters.
03
Biological functions
Embryonic developmentStem cell maintenanceCell fate specificationRegulation of proliferationRegulation of survivalImmune responseTranscription regulation
04
Disease associations
CancerDiabetes
05
Safety considerations
Aberrant Wnt pathway activation leading to tumorigenesis
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