T-cell function

T-cell function encompasses the complex biological processes that enable T lymphocytes to recognize antigens, become activated, and mount appropriate immune responses. T cells express cell-surface receptors that recognize fragments of foreign proteins displayed on host cells in association with MHC proteins[1]. The T-cell receptor complex initiates signaling cascades upon antigen recognition, leading to the activation of multiple downstream pathways and transcription factors that regulate gene expression[6][8][9]. These signaling events ultimately determine T-cell fate through controlling cytokine production, cell survival, proliferation, and differentiation[9][10]. T-cell function is critical for adaptive immunity, and dysregulation can lead to immunodeficiency, autoimmunity, or cancer. Understanding the molecular mechanisms of T-cell function has led to the development of targeted therapies for various diseases, including cancer immunotherapies and treatments for autoimmune disorders.

Other names

T lymphocyte functionT-cell receptor signalingTCR signalingT-cell-mediated immunity

Modulation of T-cell activation; Inhibition of specific signaling pathways (PI3K-mTOR, NF-κB, calcineurin); Regulation of cytokine production