T-cell homing

T-cell homing refers to the highly regulated process governing the migration of T lymphocytes from the bloodstream to specific tissues, determined by expression of surface receptors such as selectins, integrins, and chemokine receptors. These molecules interact with ligands on vascular endothelium, guiding T-cell entry into lymphoid organs, inflamed tissues, or tumors. The process is essential for normal immune surveillance, adaptive responses, and, in pathology, influences the development and outcome of inflammation, autoimmunity, cancer, and infection. Drugs targeting components of the homing machinery have clinical relevance for treating autoimmune diseases, inflammatory bowel disease, and certain cancers.

Other names

T-cell traffickingLymphocyte homingT-cell migration

Blockade of homing receptors to prevent T-cell entry to tissue; Modulation of chemokine receptor signaling; Inhibition of integrin-mediated adhesion