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Target intelligence / Profile preview
T cell immunoglobulin and ITIM domains (TIGIT)
- Target
- TIGIT
- Molecular classification
- Receptor, Poliovirus receptor-like Ig superfamily, Type I transmembrane protein
01
Overview
TIGIT (T cell immunoglobulin and ITIM domains) is an inhibitory immune receptor expressed on various lymphocyte subsets, including T cells and natural killer (NK) cells. It plays a significant role in modulating immune responses, particularly by dampening cytotoxic activity and cytokine production to maintain immune homeostasis or facilitate tumor immune evasion. It interacts with CD155/PVR (high affinity) and CD112/PVRL2/Nectin2. Blocking TIGIT has become a promising strategy in cancer immunotherapy.
- Other names
- VSIG9VSTM3WUCAM
02
Mechanism of action
Blocking TIGIT reinvigorates exhausted effector lymphocytes and reduces suppressive functions mediated by regulatory populations within tumors.
03
Biological functions
Immune inhibitionRegulation of T cell activationRegulation of NK cell cytotoxicityMaintenance of immune homeostasis
04
Disease associations
CancerChronic infectionInflammation
05
Safety considerations
Potential for immune-related adverse eventsUnintended consequences of broad immune activation
06
Interacting drugs
Anti-TIGIT antibodies
2 more in the full profile.
07
Biomarkers
TIGIT expression level on T cellsTIGIT expression level on NK cells
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