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Target intelligence / Profile preview
T-cell Immunoglobulin and Mucin-domain Containing 3 (TIM-3)
- Target
- TIM-3
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane protein, Receptor, Immune checkpoint receptor
01
Overview
T-cell immunoglobulin and mucin-domain containing 3 (TIM-3), also known as HAVCR2, is a type I transmembrane protein that functions as an immune checkpoint receptor. It is primarily expressed on various immune cells, including CD4+ T-helper type 1 (Th1) cells, CD8+ cytotoxic T lymphocytes (Tc1), regulatory T cells (Tregs), natural killer (NK) cells, dendritic cells, monocytes/macrophages, and mast cells. TIM-3 plays a critical role in regulating both innate and adaptive immune responses. Overexpression leads to impaired anti-tumor immunity and exhaustion of T cells during chronic viral infections.
- Other names
- HAVCR2
02
Mechanism of action
Blockade of TIM-3 restores anti-tumor responses; rejuvenation of antiviral immunity; modulation of inflammation
03
Biological functions
Immune responseT cell regulationInhibition of T cell effector functionsPromotion of T cell exhaustionModulation of phagocytosisModulation of inflammatory responses
04
Disease associations
CancerChronic Viral InfectionAutoimmunityHeart FailureSepsis
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