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Target intelligence / Profile preview
T-cell Immunoglobulin and Mucin Domain Containing 4 (TIM4)
- Target
- TIM4
- Molecular classification
- Receptor, Cell surface receptor, Immunoglobulin superfamily
01
Overview
TIM4 (T-cell Immunoglobulin and Mucin Domain Containing 4) is a cell surface receptor primarily known for its role in the immune system as a phosphatidylserine (PS) receptor. It is mainly expressed by antigen-presenting cells (APCs) like macrophages and dendritic cells. TIM4 recognizes PS exposed on apoptotic cell surfaces, mediating their engulfment by phagocytes, which is crucial for tissue homeostasis and preventing autoimmunity. It also modulates adaptive immunity and can be involved in allergic responses and tumor immunity. Ectopic expression has been observed in tumors and blockade is being explored as a therapeutic strategy.
- Other names
- TIMD4
02
Mechanism of action
Blockade of TIM4-phosphatidylserine interaction to enhance anti-tumor immunity.
03
Biological functions
EfferocytosisPhagocytosisImmune regulationApoptotic cell clearanceT cell modulation
04
Disease associations
AllergyAutoimmunityCancerTumor immunity
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