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Target intelligence / Profile preview
T Cell Immunoglobulin and Mucin Domain-Containing Protein 3 (TIM-3)
- Target
- TIM-3
- Molecular classification
- Immunoglobulin superfamily (IgSF), Type I transmembrane protein, Receptor
01
Overview
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), also known as Hepatitis A virus cellular receptor 2 (HAVCR2) or CD366, is an immunoregulatory protein that plays a crucial role in modulating immune responses. TIM-3 is expressed on multiple hematopoietic cell types and interacts with ligands such as Galectin-9, Phosphatidylserine, HMGB1 and CEACAM1. It regulates T cell exhaustion, immune homeostasis, TCR signaling, Treg function and myeloid cell function, and is a target for cancer immunotherapy.
- Other names
- HAVCR2Hepatitis A virus cellular receptor 2CD366
02
Mechanism of action
TIM-3 blockade may reinvigorate exhausted T cells in the tumor microenvironment
03
Biological functions
Immune regulationT cell exhaustionRegulation of TCR signalingPromotion of Treg functionModulation of myeloid cell functionImmune homeostasis
04
Disease associations
CancerSepsisInflammatory conditions
05
Biomarkers
TIM-3 expression on tumor-infiltrating lymphocytes
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