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Target intelligence / Profile preview
T cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)
- Target
- TIMD4
- Molecular classification
- Receptor, Type I transmembrane glycoprotein
01
Overview
T cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) is a type I transmembrane glycoprotein primarily expressed on antigen-presenting cells like macrophages and dendritic cells. It functions as a receptor for phosphatidylserine exposed on apoptotic cells, mediating their clearance (efferocytosis). TIMD4 also modulates adaptive immunity by interacting with TIM-1 on T cells, influencing T cell proliferation and differentiation, particularly Th2 responses. Its role in immune homeostasis makes it relevant to autoimmune disorders, allergic diseases, asthma, and cancer immunoregulation.
- Other names
- TIM-4SMUCKLERT-cell membrane protein 4
02
Mechanism of action
Not applicable - target not directly drugged, but modulated via its natural ligands
03
Biological functions
EfferocytosisApoptotic cell clearanceImmune response modulationT cell proliferation regulationPhagocytosis
04
Disease associations
AsthmaAllergic diseasesAutoimmune disordersCancer immunoregulation
05
Safety considerations
Potential for Th1/Th2 imbalanceBimodal immune regulation - can promote or inhibit immune responses depending on context
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