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Target intelligence / Profile preview
T-cell immunoglobulin domain and mucin domain-3 (TIM-3)
- Target
- TIM-3
- Molecular classification
- Type I transmembrane protein, TIM family of immunoregulatory proteins, Immune checkpoint receptor
01
Overview
TIM-3 (T-cell immunoglobulin domain and mucin domain-3), also known as HAVCR2, is a type I transmembrane protein that plays a complex role in immune regulation, acting as an immune checkpoint receptor with both inhibitory and co-stimulatory functions depending on context. Its engagement depends heavily on cellular context and microenvironmental cues, making it a promising target for cancer immunotherapy and relevant for autoimmune diseases.
- Other names
- HAVCR2
02
Mechanism of action
Blockade strategies to restore anti-tumor immunity by reversing exhaustion phenotypes among tumor-infiltrating lymphocytes.
03
Biological functions
Immune regulationT cell exhaustionCytokine secretionInhibition of IFNγ productionRegulation of Th1 responsesNK cell activationMyeloid cell stimulation
04
Disease associations
CancerAutoimmune diseasesChronic infection
05
Safety considerations
Potential for excessive inflammation/tissue damageImmune dysfunction/exhaustion
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