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Target intelligence / Profile preview
T-cell immunoglobulin mucin domain-containing protein 1 (TIM-1)
- Target
- TIM-1
- Molecular classification
- Type I transmembrane protein, Receptor
01
Overview
T-cell immunoglobulin mucin domain-containing protein 1 (TIM-1), also known as HAVCR1, is a type I transmembrane glycoprotein involved in immune regulation and various pathological processes. It acts as a stimulatory molecule for T-cell activation, particularly promoting Th2 responses. Overexpression of TIM‑1 has been observed across multiple tumor types, promoting tumor cell proliferation and resistance to apoptosis. It also functions as a cellular receptor for hepatitis A virus infection and serves as a biomarker for kidney damage under the name KIM‑1.
- Other names
- HAVCR1KIM-1
02
Mechanism of action
Inhibition of TIM-1 promotes cancer growth inhibition in preclinical models
03
Biological functions
T-cell activationCytokine secretionImmune regulationModulation of immune tolerancePromotion of Th2 responses
04
Disease associations
CancerHepatitis A virus infectionKidney damageInflammation
05
Biomarkers
KIM-1 as a biomarker for kidney damage
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