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Target intelligence / Profile preview
T cell immunoreceptor with Ig and ITIM domains (TIGIT)
- Target
- TIGIT
- Molecular classification
- Type I transmembrane protein, Immunoglobulin superfamily protein, Receptor, Immune checkpoint receptor
01
Overview
TIGIT (T cell immunoreceptor with Ig and ITIM domains) is an immune checkpoint receptor expressed on various immune cells, including T cells and NK cells. It binds to CD155 (PVR) and other ligands, delivering inhibitory signals that dampen immune responses. TIGIT plays a crucial role in regulating immune tolerance and is implicated in cancer immune evasion, making it a promising target for cancer immunotherapy.
- Other names
- VSIG9VSTM3WUCAM
02
Mechanism of action
Inhibition of TIGIT signaling by blocking its interaction with CD155, CD112, or CD113, thereby enhancing T cell and NK cell activity.
03
Biological functions
Immune regulationInhibition of T cell activationInhibition of NK cell cytotoxicityInduction of immune tolerance
04
Disease associations
CancerImmune evasion
05
Safety considerations
Immune-related adverse events (irAEs)Cytokine release syndrome
06
Interacting drugs
Anti-TIGIT monoclonal antibodies
1 more in the full profile.
07
Biomarkers
TIGIT expression levelsCD155 expression levelsTumor mutational burden (TMB)PD-L1 expression
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