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Target intelligence / Profile preview
T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT)
- Target
- TIGIT
- Molecular classification
- Immunoglobulin superfamily (IgSF), Receptor
01
Overview
TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domain) is an inhibitory immune checkpoint receptor that plays a significant role in regulating immune responses, particularly in the context of cancer and autoimmunity. It is expressed on various lymphocytes and interacts with ligands like CD155 and CD112 to suppress immune cell activation and promote immune tolerance. It is a major focus for cancer immunotherapy development.
- Other names
- VSIG9VSTM3WUCAMWashington University cell adhesion molecule
02
Mechanism of action
Engagement of TIGIT by its ligands leads to recruitment of phosphatases via its ITIM/ITT motifs, suppressing activation signals within T or NK cells. Competes with CD226 for ligand binding. Enhances suppressive activity of regulatory T-cells (Tregs).
03
Biological functions
Immune responseRegulation of T cell functionRegulation of NK cell functionSuppression of immune activation
04
Disease associations
CancerAutoimmunityChronic inflammation
05
Interacting drugs
Monoclonal antibodies targeting human TIGIT
1 more in the full profile.
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