T cell receptor alpha joining 1 (TRAJ1)

T cell receptor alpha joining 1 (TRAJ1) is a gene segment found within the T cell receptor alpha locus. This locus encodes part of the variable region of the T cell receptor alpha chain through VJ recombination, specifically, the joining (J) region of the gene. TRAJ1 is a non-functional J-segment pseudogene and does not encode a protein or function as a receptor by itself[4]. The T cell receptor as a whole is an essential immune receptor responsible for the recognition of peptide antigens bound to major histocompatibility complex (MHC) molecules, mediating T-cell activation and immune response[1][3][4]. However, TRAJ1 alone is not a therapeutic target, protein, or receptor, and is not relevant for drug targeting or as a biomarker. Key notes: - TRAJ1 is not a protein or receptor, but a genetic segment or pseudogene, and should not be considered a standalone molecular target. - If referencing a druggable target or receptor, refer to the T cell receptor alpha chain (TRAC) or the heterodimeric T cell receptor[1][6].

Other names

TRAJ1