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Target intelligence / Profile preview
T cell receptor alpha joining 20 (TRAJ20)
- Target
- TRAJ20
- Molecular classification
- Other (Gene segment; Joining segment of immunoglobulin/TCR superfamily)
01
Overview
TRAJ20 is a joining segment located in the T cell receptor alpha (TCRα) locus on chromosome 14[7]. During thymocyte development, TRAJ20 can recombine with variable (TRAV) gene segments to generate the variable region of the TCRα chain. This recombination contributes to the vast antigen recognition diversity of T cells, essential for the adaptive immune response[4][3][1]. TRAJ segments like TRAJ20 do not encode functional proteins on their own; rather, they provide DNA sequences that are recombined to form the mature TCR genes. TRAJ20 is not a receptor, enzyme, or drug target, and its clinical significance is limited to its role in TCR gene assembly and the potential impact on the immune repertoire[7][4][1].
- Other names
- TRAJ20
02
Biological functions
Generation of T cell receptor diversity (through V-J recombination in the TCRα locus)Immune response (indirectly, by enabling T cells to recognize diverse antigens)
03
Disease associations
Other (Potential involvement in diseases affecting TCR repertoire, but no specific disease role attributed to TRAJ20 segment itself)
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