T cell receptor alpha joining 33 (TRAJ33)

TRAJ33 is a joining (J) gene segment in the human T cell receptor alpha locus (TRA), encoding part of the TCR alpha chain's variable region via somatic V(J) recombination. TRAJ33 is particularly important as the canonical J segment in the TCR alpha chains of MAIT (mucosal-associated invariant T) cells—an innate-like T cell population that recognizes vitamin B metabolites presented by MR1. MAIT cell TCRs typically use TRAV1-2 (V gene) paired with TRAJ33, forming a semi-invariant TCR necessary for their antigen recognition and development[4]. During T cell development, TRAJ33 recombines with variable segments to generate diversity and specificity in TCRs expressed on the surface of MAIT cells. TRAJ33 is not a protein product, receptor, transporter, or enzyme on its own, but a genetic segment required for the assembly of functional TCR alpha chains[3][4].\n\nIf you need structured data extraction for MAIT cell TCR, that would relate to the combined TRAV1-2/TRAJ33 TCR alpha chain usage, which constitutes a semi-invariant receptor crucial for MAIT cell biology[4]. However, TRAJ33 alone should be classified as a gene segment, not a receptor or therapeutic target.

Other names

TRAJ33T-cell receptor alpha J 33TCR J alpha 33