T cell receptor alpha joining 35 (TRAJ35)

TRAJ35 refers to the "T cell receptor alpha joining 35" gene segment, one of many J (joining) segments in the *TRA* (T cell receptor alpha) locus. During T cell development, segments known as V (variable), J (joining), and C (constant) are recombined to create a diverse array of TCR alpha chains, allowing T cells to recognize a vast array of antigens[1][3][5]. TRAJ35 itself does not encode a protein or act as a receptor, but rather serves as a genetic element in the process of generating TCR diversity[1][5]. As such, it is not a direct therapeutic target or druggable protein—malfunctions or restrictions on TCR rearrangement can affect immune function but not via TRAJ35 specifically. Most references to T cell receptor drug targets pertain to the complete receptor complex or pathway, not to specific V or J gene segments like TRAJ35[2][5]. Note: Sometimes the gene symbol *TRAV35* (T cell receptor alpha variable 35) is confused with TRAJ35; both represent gene segments, not full proteins or therapeutic targets[1].

Other names

TRAJ35