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Target intelligence / Profile preview
T cell receptor alpha joining 36 (TRAJ36)
- Target
- TRAJ36
- Molecular classification
- Receptor, Other (Immunoglobulin superfamily segment)
01
Overview
T cell receptor alpha joining 36 (TRAJ36) is a gene-encoded segment that forms part of the T cell receptor (TCR) alpha chain in humans. The TCR is responsible for recognizing foreign antigens presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells. TRAJ36 encodes one of the multiple J (joining) segments used in the somatic recombination of the TCR alpha chain, providing diversity crucial for adaptive immunity. TCR loci rearrangement during T cell development allows a wide range of antigen recognition through various combinations of V (variable), J (joining), and C (constant) gene segments. TRAJ36 itself does not encode a full functional protein, but rather contributes as a recombined DNA segment to the TCR alpha variable region. There is no evidence for TRAJ36 as a direct therapeutic target, nor is it currently associated with drug interactions, biomarker status, or notable safety concerns.
- Other names
- TRAJ36T cell receptor alpha joining segment 36
02
Biological functions
Immune responseAntigen recognition
03
Disease associations
Other (no specific direct association with diseases, but involved in general T cell function)
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