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Target intelligence / Profile preview
T cell receptor alpha joining 48 (TRAJ48)
- Target
- TRAJ48
- Molecular classification
- Other (T cell receptor joining gene segment), Gene segment (Immunoglobulin/TCR gene segment)
01
Overview
T cell receptor alpha joining 48 (TRAJ48) is a germline gene segment located within the TCR alpha locus on chromosome 14. During T cell development, TRAJ48 can be selected as the J (joining) region in somatic recombination, joining a V (variable) segment and subsequently contributing to the CDR3 antigen-binding region of the T cell receptor alpha chain. This process generates receptor diversity critical for recognizing a broad array of antigens presented by the major histocompatibility complex (MHC) molecules. TRAJ48 is not expressed as a standalone protein or functional receptor but constitutes an essential building block in the genetic generation of diverse TCRs necessary for adaptive immunity.
- Other names
- TRAJ48
02
Biological functions
Immune response (Antigen receptor diversity)Other (T cell development, adaptive immunity)
03
Disease associations
Other (Not directly disease-causative; alterations in TCR gene recombination in general may impact immune function or be involved in leukemia/lymphoma, but individual J segments like TRAJ48 have not been specifically implicated)
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