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Target intelligence / Profile preview
T cell receptor alpha joining 6 (TRAJ6)
- Target
- TRAJ6
- Molecular classification
- Other (Gene segment), T cell receptor gene segment, Not a conventional receptor, enzyme, transporter, etc.
01
Overview
TRAJ6 is a joining gene segment within the human T cell receptor alpha locus. During T cell development, TRAJ6 can be joined with any one of many variable (TRAV) segments to form the variable region of the T cell receptor alpha chain. This recombination generates antigen specificity and diversity required for immune recognition. The TCR itself is a heterodimeric, membrane-anchored protein critical for antigen recognition, T cell activation, and adaptive immunity. TRAJ6 is therefore a genetic component necessary for T cell receptor construction, not a functional protein or therapeutic target.
- Other names
- TRAJ6HGNC:12092NCBI Gene:28749Ensembl:ENSG00000211883
02
Biological functions
Adaptive immune response (as part of the T cell receptor recombination machinery)Generation of antigen recognition diversityLymphocyte development
03
Disease associations
Other (TRAJ6 itself is not directly implicated in disease, but errors in TCR recombination can affect immunity)General relevance to immune deficiencies and T cell-mediated diseases via its role in TCR diversity
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