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Target intelligence / Profile preview
T cell receptor alpha joining 60 (TRAJ60)
- Target
- TRAJ60
- Molecular classification
- Other (gene segment, not a protein), Immunoglobulin gene segment (part of the T cell receptor alpha/delta locus)
01
Overview
T cell receptor alpha joining 60 (TRAJ60) is a joining (J) gene segment within the T cell receptor (TCR) alpha locus, contributing to the diversity of TCRs through V(D)J recombination during T cell development. In the human genome, TRAJ60 is annotated as a pseudogene and does not encode a functional protein. J segments like TRAJ60 serve as short DNA sequences recombined with V (variable) segments to generate the unique antigen receptor of each T cell, essential for adaptive immunity. However, TRAJ60 itself is not a functional receptor, enzyme, or classical molecular target, and has no direct therapeutic relevance. TRAJ60 is not a standalone molecular entity but rather a genetic segment within the TCR alpha locus, mainly important for gene recombination in T cell development, and not considered a therapeutic target, protein family member, or direct disease marker.
- Other names
- TCRAT cell receptor alpha joining 60TRAJ60
02
Biological functions
Locus segment contributing to diversity of antigen recognition in T cells (via V(D)J recombination)Provides joining sequence in the variable region of T cell receptor alpha chain
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