T-cell receptor and B-cell receptor interaction via major histocompatibility complex (TCR-BCR/MHC)

The T-cell receptor (TCR) is a membrane-bound heterodimer (usually alpha/beta chains) that recognizes peptide antigens presented on the major histocompatibility complex (MHC) of antigen-presenting cells, triggering signal transduction cascades that result in T cell activation and immune response[1][3][9][10]. B-cell receptors (BCR) are membrane-bound immunoglobulin proteins that recognize native antigens; after activation, B cells can present processed antigen via MHC class II to T cells, allowing for further activation and differentiation[1][5][2]. The TCR-MHC and BCR-MHC axes are crucial for adaptive immunity and are focal points for immunotherapeutic intervention. The combination "TCR/BCR via MHC complex" is not canonical, commonly representing the interplay between these two receptor systems during immune response but is not a standard single molecular target. It is more appropriate to separately refer to "T-cell receptor/MHC complex interaction" and "B-cell receptor signaling and antigen presentation via MHC."

Other names

TCR-MHC interactionT-cell receptor/major histocompatibility complex axisBCR-MHC interaction (less common, refers to B cell antigen presentation)T-cell antigen receptorB-cell antigen receptor

Immunomodulation (inhibition or activation of T-cell or B-cell receptor signaling) Blockade of co-stimulatory or inhibitory signals (e.g., PD-1/PD-L1, CTLA-4) Tyrosine kinase inhibition (e.g., BTK, Syk, PI3K in B cell signaling) Activation or downregulation of cytokine secretion